WHAT is this: A Practice Tool to Assist with Clinical Decision Making for Appropriate Probiotic Therapy for Your Patients WHO is the intended user: This Clinical Guide is designed to translate scientific evidence available for probiotic products to practical, clinically relevant information. It is intended to be used as clinical decision-making tool, enabling clinicians to easily select the appropriate product, dose, and formulation for a specific indication. WHY is this needed: Currently, the body of evidence for probiotic interventions is growing along with popular demand for these products. There is evidence to support the use of probiotic products for a variety of indications beyond gut health, however applications and results are strain-specific. Due to frequent changes in commercial availability of probiotic strains, new published evidence and growing research, an annual review and updates of this Clinical Guide has been conducted since 2008. A general lack of adverse effects attributable to probiotics supports the wide use of these products, but ongoing investigation is recommended.